I did a 6 man State championship last season (Throckmorton/Borden County) and it was fantastic.
Despite getting a really nice 4a/5a schedule this year, I am going to try to do as much 6 man as possible anytime that I am available. I absolutely LOVE the 6 man game.
Despite doing a lot more running, the game itself is so wide open and a lot easier to call in certain regards.
The only real differences is that you only need 3 on the line (technically no more than 3 in the backfield, but you do the math), 2 exchanges before a run, and everyone is an eligible receiver. (Center needs at least 1 yard difference between him and the passer) Plus you kill extra point kicks on a defensive procession or when the kick is no good, kickoff is from the 30, its 15 yards for a 1st down, 10 minute quarters, 45 point mercy rule after the 2nd quarter, linemen can take forward handoffs behind the line of scrimmage, etc.
The Amarillo chapter is now requiring ALL crews to do at least 1 6 man varsity game, which I think is fantastic. (We have a LOT of 6 man teams in our area)
We have ours Saturday. 6-man football is fantastic! Even if you're a little confused at first, you'll grow to love it. Let me know if you have any specific questions.